Determination of p-aminosalicylic acid as m-aminophenol

Determination of n-acetyl-p-aminophenol in plasma.

Two methods for the determination of N-acetyl-p-aminophenol (APAP) in plasma that differ in principle from the diazotization procedure of Brodie and Axelrod (1) are described. One method based on the differential absorption peak of APAP at 266 m, which corresponds to the isosbestic point of common drugs such as acetylsalicylic and salicylic acids, is simple and most specific for APAP. The other...

The differential determination of mixtures of p-aminosalicylic acid and sulphetrone or sulphonamides in body fluids.

Mechanism of competitive inhibition of p-aminobenzoic acid oxidation by p-aminosalicylic acid.

The proposed mechanism(s) associated with the inhibition of essential metabolic reactions by various compounds has received a great deal of attention in recent years, since antimetabolites have proved useful in several chemotherapeutic areas and in studying various metabolic reactions. The significance of p-aminobenzoic acid in microbial nutrition was first emphasized when Woods (1940) and Wood...

Quantitative determination of p-aminosalicylic acid and its degradation product m-aminophenol in pellets by ion-pair high-performance liquid chromatography applying the monolithic Chromolith Speedrod RP-18e column.

An ion-pair high performance liquid chromatographic method was developed for the simultaneous determination of p-aminosalicylic acid (PAS) and its degradation product m-aminophenol (MAP) in a newly developed multiparticular drug delivery system. Owing to the concentration differences of PAS and MAP, acetanilide and sulfanilic acid were used as internal standards, respectively. The separation wa...

P-aminophenol excretion as an index of aniline exposure.

In view of the fact that aniline is absorbed not only by inhalation but also through the skin, the aerial contamination alone is not an exact indication of exposure. It is necessary to find a biological test which reveals exposure and is independent of the route of absorption. It is conceivable that the p-aminophenol excretion in the urine, which is a well-known symptom of aniline intoxication,...